Structure of PDB 4rxr Chain B

Receptor sequence
>4rxrB (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGSQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLG
GGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQI
AGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIK
PVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRN
GIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEV
GNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKK
YRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKY
VGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMD
YGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKK
VDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
3D structure
PDB4rxr The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
ChainB
Resolution2.117 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B Y155 V156 V378 R451 Y54 V55 V272 R345
BS02 DCP B V156 F157 R372 H376 K377 V55 F56 R266 H270 K271
BS03 GTP B K116 V117 I118 D137 Q142 R145 K15 V16 I17 D36 Q41 R44
BS04 DCP B Q149 L150 R164 H215 K312 Y315 D319 R366 H370 Y374 Q48 L49 R63 H114 K206 Y209 D213 R260 H264 Y268
External links
PDB RCSB:4rxr, PDBe:4rxr, PDBj:4rxr
PDBsum4rxr
PubMed25760601
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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