Structure of PDB 4rxq Chain B

Receptor sequence

>4rxqB (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]

NLYFQGSQIHVDTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLG
GGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQI
AGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIK
PVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRN
GIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEV
GNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKK
YRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKY
VGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMD
YGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKK
VDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4rxq The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	B	K116 V117 I118 D137 R145	K15 V16 I17 D36 R44
BS02	DUT	B	V117 N119	V16 N18
BS03	GTP	B	Y155 V156 V378 R451 K455	Y54 V55 V272 R345 K349
BS04	DUT	B	Q149 L150 R164 H215 D309 D311 K312 Y315 D319 R366 H370 Y374	Q48 L49 R63 H114 D203 D205 K206 Y209 D213 R260 H264 Y268
BS05	DUT	B	V156 F157 R372 H376 K377	V55 F56 R266 H270 K271

External links

PDB	RCSB:4rxq, PDBe:4rxq, PDBj:4rxq
PDBsum	4rxq
PubMed	25760601
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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