Structure of PDB 4rxh Chain B

Receptor sequence

>4rxhB (length=421) Species: 5141 (Neurospora crassa)

DLPKMVEGVFSSEIDKQIQATTKFRKLLSKERNPPIEEVIKTGVVGRFVE
FLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPD
VREQAVWALGNIAGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATW
TLSNFCRGKTPQPDWNTIAPALPVLAKLVYSLDDEVLIDACWAISYLSDG
SNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVI
INCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQSVIDANIIPP
LIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIKPLCDLL
ACPDNKIIQVALDGLENILKVGELDKNAASINRYALFIEECGGMEKIHDC
QTNANEEIYMKAYNIIEKYFS

3D structure

• PDB: 4rxh Structure of Importin-alpha from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
• Chain: B
• Resolution: 1.7553 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	D280 G281 N283 T322 G323 W357 N361 A364 E396 W399 N403	D199 G200 N202 T241 G242 W276 N280 A283 E315 W318 N322
BS02	peptide	B	L109 S110 K111 E112 P115 W146 N150 A152 S153 G154 Q185 W188 N192 G195 D196 W231 R238 W273	L28 S29 K30 E31 P34 W65 N69 A71 S72 G73 Q104 W107 N111 G114 D115 W150 R157 W192

Gene Ontology

Molecular Function

• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4rxh, PDBe:4rxh, PDBj:4rxh
• PDBsum: 4rxh
• PubMed: 26091498
• UniProt: Q9C2K9