Structure of PDB 4rlo Chain B

Receptor sequence
>4rloB (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKKHPFIVD
LIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALG
HLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESITIEYMAPEILMRS
GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ
EARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPP
FKPL
3D structure
PDB4rlo Development of Organometallic S6K1 Inhibitors.
ChainB
Resolution2.527 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D111 K113 E115 N116 D129 T138
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU B L97 G98 V105 A121 E173 Y174 L175 E222 M225 L13 G14 V21 A37 E66 Y67 L68 E115 M118
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rlo, PDBe:4rlo, PDBj:4rlo
PDBsum4rlo
PubMed25356520
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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