Structure of PDB 4rkz Chain B

Receptor sequence
>4rkzB (length=318) Species: 273075 (Thermoplasma acidophilum DSM 1728) [Search protein sequence]
GSMTYRSIGSTAYPTIGVVLLGGIANPVTRTPLHTSAGIAYSDSCGSIRS
ETRIYADEATHIYFNGTESDNRSVRRVLDRYSSVFEEAFGTKTVSYSSQN
FGILSGSSDAGAASIGAAILGLKPDLDPHDVENDLRAVSESAGRSLFGGL
TITWSDGFHAYTEKILDPEAFSGYSIVAFAFDYQRNPSDVIHQNIVRSDL
YPARKKHADEHAHMIKEYAKTNDIKGIFDLAQEDTEEYHSILRGVGVNVI
RENMQKLISYLKLIRKDYWNAYIVTGGSNVYVAVESENADRLFSIENTFG
SKKKMLRIVGGAWHRRPE
3D structure
PDB4rkz Structural analysis of mevalonate-3-kinase provides insight into the mechanisms of isoprenoid pathway decarboxylases.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.185: mevalonate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3S4 B L18 L19 S105 E140 R144 R185 T275 L20 L21 S105 E140 R144 R185 T275
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4rkz, PDBe:4rkz, PDBj:4rkz
PDBsum4rkz
PubMed25422158
UniProtQ9HIN1|MV3K_THEAC Mevalonate 3-kinase (Gene Name=Ta1305)

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