Structure of PDB 4rib Chain B

Receptor sequence
>4ribB (length=628) Species: 9606 (Homo sapiens) [Search protein sequence]
TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYV
RLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVL
ELLSAPELKSLAKTFHLANPNGQKQQLVDAFLKLAKQRSVIGAVILKRAK
ALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN
LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAK
ELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQ
RLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKC
ITEGLADPEVRTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK
HVTITGRLCPQRKSVFVMEAGEAADPTTVLCSVEELALAHYRRSGFDQGI
HGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRP
ALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSWDRFTSLQQAQDL
VSCLGGPVLSGVCRHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPND
RLSHKQMIWLAELQKLGAEVEVCHVVAV
3D structure
PDB4rib DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
ChainB
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y374 R420 R424 K425 Y436 Y5 R51 R55 K56 Y67 PDBbind-CN: Kd=10.3nM
BS02 dna B K433 S473 A474 K493 K64 S104 A105 K124 PDBbind-CN: Kd=10.3nM
BS03 CA B D960 E975 V976 D579 E594 V595
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rib, PDBe:4rib, PDBj:4rib
PDBsum4rib
PubMed25430771
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

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