Structure of PDB 4ria Chain B

Receptor sequence
>4riaB (length=613) Species: 9606 (Homo sapiens) [Search protein sequence]
TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYV
RLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVL
ELLSAPELKSLAKTFHLANPNGQKQQLVDAFLKLAKQRSVIGAVILKRAK
ALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN
LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAK
ELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQ
RLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKC
ITEGLADPEVRTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK
HVTITGRLCVFVMVLCSVEELALAHYRRSGFDQGIHGEGSTFSTLYGLLL
WDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAPEE
SLRAWVAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRH
LAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAELQK
LGAEVEVCHVVAV
3D structure
PDB4ria DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H742 R952 N980 K986 H364 R556 N584 K590
BS02 dna B Y374 R420 R424 K425 Y436 T573 Y5 R51 R55 K56 Y67 T195
BS03 dna B R679 H681 R710 H718 R749 R752 R982 R301 H303 R332 H340 R371 R374 R586
BS04 dna B K493 T573 W624 K124 T195 W246
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ria, PDBe:4ria, PDBj:4ria
PDBsum4ria
PubMed25430771
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

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