Structure of PDB 4ri5 Chain B

Receptor sequence
>4ri5B (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
SNADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKN
RYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT
CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQC
QSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPEHGVPDDSSDFLEF
VNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV
RKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQ
3D structure
PDB4ri5 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
ChainB
Resolution1.26 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E811 C842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) E187 C218 R224 T225 Q262
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VN4 B C842 S843 A844 G845 I846 G847 R848 C218 S219 A220 G221 I222 G223 R224
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ri5, PDBe:4ri5, PDBj:4ri5
PDBsum4ri5
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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