Structure of PDB 4rhu Chain B

Receptor sequence
>4rhuB (length=178) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
AELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLLITVL
KGAVLFVTDLARAIPVPTQFEFMAVSSYGVVRILKDLDRDIHGRDVLIVE
DVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVNVEIAYVGFDIPND
FVVGYGLDYDERYRDLSYIGTLDPRVYQ
3D structure
PDB4rhu First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
ChainB
Resolution2.573 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E122 D123 D126 F175 R188
Catalytic site (residue number reindexed from 1) E100 D101 D104 F151 R164
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3QE B G67 V124 D126 S127 G128 T130 K154 F175 V176 D182 R188 G52 V102 D104 S105 G106 T108 K132 F151 V152 D158 R164 PDBbind-CN: -logKd/Ki=6.16,Ki=0.69uM
BS02 MG B E122 D123 E100 D101
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006177 GMP biosynthetic process
GO:0006178 guanine salvage
GO:0006188 IMP biosynthetic process
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0043101 purine-containing compound salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4rhu, PDBe:4rhu, PDBj:4rhu
PDBsum4rhu
PubMed25915781
UniProtP9WHQ9|HGPRT_MYCTU Hypoxanthine-guanine phosphoribosyltransferase (Gene Name=hpt)

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