Structure of PDB 4rf2 Chain B

Receptor sequence
>4rf2B (length=250) Species: 33962 (Lentilactobacillus kefiri) [Search protein sequence]
DRLKGKVAIVTGGTLGIGLAIADKFVEEGAKVVITGRHADVGEKAAKSIG
GTDVIRFVQHDASDEAGWTKLFDTTEEAFGPVTTVVNNAGIAVSKSVEDT
TTEEWRKLLSVNLDGVFFGTRLGIQRMKNKGLGASIINMSSIEGFVGDPT
LGAYNASKGAVRIMSKSAALDCALKDYDVRVNTVHPGYIKTPLVDDLEGA
EEMMSQRTKTPMGHIGEPNDIAWICVYLASDESKFATGAEFVVDGGYTAQ
3D structure
PDB4rf2 Origins of stereoselectivity in evolved ketoreductases.
ChainB
Resolution2.089 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G18 S143 Y156 K160
Catalytic site (residue number reindexed from 1) G16 S141 Y154 K158
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G14 L17 I19 R39 H40 D63 A64 N90 A91 V113 M141 S143 Y156 K160 P188 Y190 I191 T193 P194 L195 G12 L15 I17 R37 H38 D61 A62 N88 A89 V111 M139 S141 Y154 K158 P186 Y188 I189 T191 P192 L193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4rf2, PDBe:4rf2, PDBj:4rf2
PDBsum4rf2
PubMed26644568
UniProtQ6WVP7|RADH_LENKE NADP-dependent (R)-specific alcohol dehydrogenase (Gene Name=adh)

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