Structure of PDB 4rak Chain B

Receptor sequence
>4rakB (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPDARQQRFAHFTELAI
ISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETEC
ITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAI
NIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLV
SLRTLSSVHSEQVFALRLQDKKLPPLLSEIWD
3D structure
PDB4rak Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXR beta.
ChainB
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 652 B F268 F271 T272 L274 A275 S278 I309 M312 L313 E315 T316 R319 F329 L330 F340 F349 H435 W457 F42 F45 T46 L48 A49 S52 I83 M86 L87 E89 T90 R93 F103 L104 F114 F123 H209 W231 MOAD: Ki=14nM
BindingDB: EC50=250nM,Ki=14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4rak, PDBe:4rak, PDBj:4rak
PDBsum4rak
PubMed25435151
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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