Structure of PDB 4r8d Chain B

Receptor sequence
>4r8dB (length=365) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRS
VREAAIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEIL
QQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDV
AVAAVVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGE
FSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGRLGYLIATPAVIDAMLL
VRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLNDMGFRV
IPSDANFVLFGEFADAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEEND
AFLRASARIATDLVP
3D structure
PDB4r8d Crystal structure of Rv1600 encoded aminotransferase in complex with PLP-MES from Mycobacterium tuberculosis
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.9: histidinol-phosphate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G101 S102 N103 Y127 N176 D201 A203 Y204 T229 S231 K232 R240 G95 S96 N97 Y121 N170 D195 A197 Y198 T223 S225 K226 R234
Gene Ontology
Molecular Function
GO:0004400 histidinol-phosphate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0000105 L-histidine biosynthetic process
GO:0009058 biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r8d, PDBe:4r8d, PDBj:4r8d
PDBsum4r8d
PubMed
UniProtP9WML7|HIS8_MYCTU Histidinol-phosphate aminotransferase (Gene Name=hisC)

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