Structure of PDB 4r82 Chain B

Receptor sequence
>4r82B (length=165) Species: 1908 (Streptomyces globisporus) [Search protein sequence]
AELVDPKDRVQLRRVFGDFPTGVTVVTVGGSEPRGMTANSFTSVSLSPPL
VLICVGKDAVMHQRLTALPTFAVSVLEAGQEKAARHFADHSVDQFDTVDW
VLGEESGAPLIAGAVAHLECAIHRLYEGGDHTIFLGEVITATRWPAREGM
LFSGGRFRRFAPDAD
3D structure
PDB4r82 Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
ChainB
Resolution1.659 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.37: FAD reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B R21 F24 G25 H143 R13 F16 G17 H131
BS02 NAD B R21 H143 R13 H131
BS03 CA B P157 R159 P145 R147
BS04 FAD B M44 T45 A46 N47 S48 C62 V63 A67 A96 F164 M36 T37 A38 N39 S40 C54 V55 A59 A88 F152
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
GO:0042602 riboflavin reductase (NADPH) activity
Biological Process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4r82, PDBe:4r82, PDBj:4r82
PDBsum4r82
PubMed27560143
UniProtQ8GME2|SGCE6_STRGL NADH-dependent FAD reductase (Gene Name=sgcE6)

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