Structure of PDB 4r7p Chain B

Receptor sequence
>4r7pB (length=485) Species: 9606 (Homo sapiens) [Search protein sequence]
IRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSV
DWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGC
KGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKK
ILQKYNHCRVKIYTFNQSRYPRINKESLLPVAKDVSYSGENTEAWYPPGH
GDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLMNPPNG
KRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSK
FKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVG
AAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKRE
FPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLK
GTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
3D structure
PDB4r7p A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism.
ChainB
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.9: UTP--glucose-1-phosphate uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B N179 H180 N156 H157
Gene Ontology
Molecular Function
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0016779 nucleotidyltransferase activity
GO:0032557 pyrimidine ribonucleotide binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051748 UTP-monosaccharide-1-phosphate uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006011 UDP-glucose metabolic process
GO:0006065 UDP-glucuronate biosynthetic process
GO:0007420 brain development
GO:0019255 glucose 1-phosphate metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r7p, PDBe:4r7p, PDBj:4r7p
PDBsum4r7p
PubMed25860585
UniProtQ16851|UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase (Gene Name=UGP2)

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