Structure of PDB 4r3v Chain B

Receptor sequence
>4r3vB (length=179) Species: 203275 (Tannerella forsythia 92A2) [Search protein sequence]
QRLYDNGPLTGDNNYVLQGSKWNKTTLKYYIYNSSSHLTTTERENAIRSA
FALWSDKSTLSFIQVYNPNQADIKIKWEKGNHGDGYPFDGNTGILAHAFY
PPPAGGNYAGHLHFDGDENWSINGSGIDLITVAAHAIGHLLGIEHSNVSS
ALMYPYYTGIKRQLDNDDCLAVWDLYGYP
3D structure
PDB4r3v A novel mechanism of latency in matrix metalloproteinases.
ChainB
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H155 A156 H159 H165
Catalytic site (residue number reindexed from 1) H135 A136 H139 H145
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D25 H155 H159 H165 D5 H135 H139 H145
BS02 ZN B H102 D104 H117 H133 H82 D84 H97 H113
BS03 CA B D109 G110 T112 I114 D135 E138 D89 G90 T92 I94 D115 E118
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Cellular Component
External links
PDB RCSB:4r3v, PDBe:4r3v, PDBj:4r3v
PDBsum4r3v
PubMed25555916
UniProtD0EM77|KLY_TANFA Karilysin (Gene Name=kly)

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