Structure of PDB 4r09 Chain B

Receptor sequence

>4r09B (length=752) Species: 9606 (Homo sapiens)

RSYPCDEKKQDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNES
FQGLQNLTKINLNHNPNVQNGLNITDGAFLNLKNLRELLLEDNQLPQIPS
GLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNI
EDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDF
KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYL
NLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL
DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQ
LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPDFEFDPHSNF
YHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSN
AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHY
FRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSG
NRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLT
ELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTL
LLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML
ELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL
EL

3D structure

• PDB: 4r09 Toll-like receptor 8 senses degradation products of single-stranded RNA.
• Chain: B
• Resolution: 2.62 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	URI	B	D543 D545 V573 T574	D476 D478 V506 T507
BS02	URI	B	Y348 Y353 V378 F405 R429	Y306 Y311 V336 F363 R387
BS03	06S	B	Y291 K314 I341 D343 H373 R375 N400 H469 F470 T471 L474	Y249 K272 I299 D301 H331 R333 N358 H402 F403 T404 L407
BS04	UPT	B	F265 F320 F346 R375 F467 Y468 F470	F223 F278 F304 R333 F400 Y401 F403

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4r09, PDBe:4r09, PDBj:4r09
• PDBsum: 4r09
• PubMed: 25599397
• UniProt: Q9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)