Structure of PDB 4r08 Chain B

Receptor sequence
>4r08B (length=737) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYPCDEKKVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQG
LQNLTKINLNHNPNVGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPES
LTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVF
ETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLIN
LTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSST
SLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFN
YIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS
TINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPFEFDPHSNFYHFTRP
LIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSG
TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGV
THHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDIL
WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHIND
NMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNR
ISHLPSGFLSEVSSLKHLDLSSNLLKTINKSAKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSL
3D structure
PDB4r08 Toll-like receptor 8 senses degradation products of single-stranded RNA.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 URI B D543 D545 V573 T574 D470 D472 V500 T501 MOAD: Kd=55uM
BS02 URI B Y348 V378 F405 R429 Y301 V331 F358 R382 MOAD: Kd=55uM
BS03 UCG B K314 V315 I341 D343 H373 R375 H469 F470 T471 R472 P473 L474 K267 V268 I294 D296 H326 R328 H396 F397 T398 R399 P400 L401
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4r08, PDBe:4r08, PDBj:4r08
PDBsum4r08
PubMed25599397
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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