Structure of PDB 4qxr Chain B

Receptor sequence
>4qxrB (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWAYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQQTIDRAGIKDRVYSNSIYELLENGQR
AGTCVLEYATPLITLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAP
ESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQ
3D structure
PDB4qxr Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
ChainB
Resolution2.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YE B G166 R238 G13 R85 MOAD: Kd=0.99uM
PDBbind-CN: -logKd/Ki=6.00,Kd=0.99uM
BS02 1YE B A162 T263 T267 A9 T110 T114 MOAD: Kd=0.99uM
PDBbind-CN: -logKd/Ki=6.00,Kd=0.99uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4qxr, PDBe:4qxr, PDBj:4qxr
PDBsum4qxr
PubMed25199835
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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