Structure of PDB 4qxp Chain B

Receptor sequence
>4qxpB (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQQTIDRAGIKDRVYSNSIYELLENGQR
AGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAP
ESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQ
3D structure
PDB4qxp Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
ChainB
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YE B S162 G166 R238 S9 G13 R85
BS02 1YE B S162 Y167 T263 T267 S9 Y14 T110 T114
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4qxp, PDBe:4qxp, PDBj:4qxp
PDBsum4qxp
PubMed25199835
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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