Structure of PDB 4qxd Chain B

Receptor sequence
>4qxdB (length=289) Species: 294381 (Entamoeba histolytica HM-1:IMSS) [Search protein sequence]
MQTSLFEFANVLITAVKEASYSISKFKEEVEIKYKSDGSEVTQVDTQSQQ
IIFSIIKNKYPTINIIGEEDVENGIPDNQLPTITQLSFGSLENKIININD
IIIYVDPLDGTDCYTHKQYDSVCVLVGVTYKGKPMIGIVSKPFYNNEITF
AIENYISSISLQPLNDKIIFVCSKKNDIQHLIKSFPDPYEVKYKGGSGAK
MMAIIHQEADIYYHPLIQSCTWDTLAAQVILEAQGGIVCDIYGNPLCYPS
SKKESMRHKKGVLCLSPRAKKYLPYMLSISKTILLLQHH
3D structure
PDB4qxd Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica
ChainB
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E68
Catalytic site (residue number reindexed from 1) E68
Enzyme Commision number 3.1.3.57: inositol-1,4-bisphosphate 1-phosphatase.
3.1.3.7: 3'(2'),5'-bisphosphate nucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E68 D106 L108 D109 E68 D106 L108 D109
BS02 MG B D106 D109 D223 D106 D109 D223
BS03 PO4 B E68 L108 D109 G110 T111 E68 L108 D109 G110 T111
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity
GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:4qxd, PDBe:4qxd, PDBj:4qxd
PDBsum4qxd
PubMed25372691
UniProtC4M633|INPP_ENTH1 Inositol polyphosphate 1-phosphatase (Gene Name=EHI_179820)

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