Structure of PDB 4qww Chain B

Receptor sequence
>4qwwB (length=529) Species: 8613 (Bungarus fasciatus) [Search protein sequence]
AGELKVSTQTGSVRGLSLPVLDGHVSAFLGIPFAEPPLGRMRFLRPEPVK
PWQHVLDATSYKPACYQMVDTSYPGFQGTEMWNPNRGMSEDCLYLNIWVP
SPRPKDAPVLVWIYGGGFYSGAASLDVYDGRFLTYTQNVILVSLSYRVGA
FGFLGLPGSPEAPGNMGLLDQRLALQWIQNNIHPFGGNPRAVTVFGESAG
AASVGMHLLSTQSRTLFQRAILQSGGPNAPWATVTPAESRGRAALLGKQL
GCHFNNDSELVSCLRSKNPQELIDEEWSVLPYKSIFRFPFVPVIDGDFFP
DTPEAMLSSGNFKETQVLLGVVKDEGSYFLIYGLPGFSKDNESLISRADF
LEGVRMSVPHANDIATDAVVLQYTDWQDQDNREKNREALDDIVGDHNVIC
PVVQFANDYAKRNSKVYAYLFDHRASNLLWPPWMGVPHGYEIEFVFGLPL
NDSLNYTPQEKELSRRMMRYWANFARTGNPTDPAAWPTYTASQPQYVQLN
TQPLATQPSLRAQICAFWNHFLPKLLNAT
3D structure
PDB4qww Crystal Structure of Snake Venom Acetylcholinesterase in Complex with Inhibitory Antibody Fragment Fab410 Bound at the Peripheral Site: EVIDENCE FOR OPEN AND CLOSED STATES OF A BACK DOOR CHANNEL.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G118 G119 G151 S200 A201 A239 F290 F292 E327 H440
Catalytic site (residue number reindexed from 1) G116 G117 G149 S198 A199 A237 F288 F290 E325 H438
Enzyme Commision number 3.1.1.7: acetylcholinesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B T61 S62 T59 S60
Gene Ontology
Molecular Function
GO:0003990 acetylcholinesterase activity
GO:0004104 cholinesterase activity
GO:0052689 carboxylic ester hydrolase activity
GO:0090729 toxin activity
Biological Process
GO:0001507 acetylcholine catabolic process in synaptic cleft
GO:0006581 acetylcholine catabolic process
GO:0019695 choline metabolic process
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0043083 synaptic cleft
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qww, PDBe:4qww, PDBj:4qww
PDBsum4qww
PubMed25411244
UniProtQ92035|ACES_BUNFA Acetylcholinesterase (Gene Name=ACHE)

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