Structure of PDB 4qvh Chain B

Receptor sequence

>4qvhB (length=595) Species: 83332,83333 [Search protein sequence]

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYGKYDIKDVGVDNAGAKAGLTFLVDLIKNK
HMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKG
QPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAV
ALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAAS
GRQTVDAALAAAQTNAAAMTVGTLVASVLPATVFEDLAYAELYSDPPGLT
PLPEEAPLIARSVAKRRNEFITVRHCARIALDQLGVPPAPILKGDKGEPC
WPDGMVGSLTHCAGYRGAVVGRRDAVRSVGIDAEPHDVLPNGVLDAISLP
AERADMPRTMPAALHWDRILFCAKEATYKAWFPLTKRWLGFEDAHITFET
DSTGWTGRFVSRILIDGSTLSGPPLTTLRGRWSVERGLVLTAIVL

3D structure

PDB

4qvh Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein.

Chain

Resolution

1.75 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

?
2.7.8.7: holo-[acyl-carrier-protein] synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GLC	B	D15 K16 E112 Y156 W231	D14 K15 E111 Y155 W228
BS02	GLC	B	W63 D66 R67 E154 P155 Y156 W341	W62 D65 R66 E153 P154 Y155 W338
BS03	COA	B	R419 R427 K446 K449 G450 E451 P452 L462 T463 H464 D485 K527 E528 Y531 K532 F535 W541 L542 G543 F544	R416 R424 K443 K446 G447 E448 P449 L459 T460 H461 D482 K524 E525 Y528 K529 F532 W538 L539 G540 F541
BS04	MG	B	D485 A486 E487	D482 A483 E484

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0005515	protein binding
GO:0008897	holo-[acyl-carrier-protein] synthase activity
GO:0015144	carbohydrate transmembrane transporter activity
GO:0016740	transferase activity
GO:0046872	metal ion binding
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0009237	siderophore metabolic process
GO:0015768	maltose transport
GO:0019290	siderophore biosynthetic process
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4qvh, PDBe:4qvh, PDBj:4qvh
PDBsum	4qvh
PubMed	25450595
UniProt	O33336\|PPTT_MYCTU 4'-phosphopantetheinyl transferase PptT (Gene Name=pptT); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

[Back to BioLiP]