Structure of PDB 4qu3 Chain B

Receptor sequence
>4qu3B (length=265) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
EKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFP
LAALVFERIDSGTERGDRKLSYGPDMIVEWSPATERFLASGHMTVLEAAQ
AAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTP
GDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAG
FPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDE
LVASVGQVITQLILS
3D structure
PDB4qu3 Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type beta-Lactamases.
ChainB
Resolution1.402 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S64 K67 S125 E161 K229 T232
Catalytic site (residue number reindexed from 1) S45 K48 S106 E142 K210 T213
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1RG B C63 S64 W99 S125 N127 N165 T230 G231 T232 C44 S45 W80 S106 N108 N146 T211 G212 T213
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:4qu3, PDBe:4qu3, PDBj:4qu3
PDBsum4qu3
PubMed25485972
UniProtQ93F76|BLAG2_PSEAI Beta-lactamase GES-2 (Gene Name=blaGES-2)

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