Structure of PDB 4qrh Chain B

Receptor sequence
>4qrhB (length=186) Species: 1458279 (Staphylococcus aureus USA300-ISMMS1) [Search protein sequence]
DNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVD
GVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVF
LEIEVEGAKQVRKKFPDALFIFLAPPSLEHLNEARKEVEMMNLYDYVVVN
DEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAK
3D structure
PDB4qrh Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp.
ChainB
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.8: guanylate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0O2 B G16 V17 G18 K19 S39 R43 Y55 E74 Y78 Y83 G84 E103 I104 E105 G15 V16 G17 K18 S38 R42 Y54 E73 Y77 Y82 G83 E102 I103 E104 MOAD: Ki=7uM
PDBbind-CN: -logKd/Ki=5.15,Ki=7.0uM
Gene Ontology
Molecular Function
GO:0004385 guanylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0016310 phosphorylation
GO:0046037 GMP metabolic process
GO:0046710 GDP metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4qrh, PDBe:4qrh, PDBj:4qrh
PDBsum4qrh
PubMed25661490
UniProtA0A0J9X1Z9

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