Structure of PDB 4qn6 Chain B

Receptor sequence
>4qn6B (length=389) Species: 215864 (Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6))) [Search protein sequence]
GTFLNLTKPLCEVSSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRM
FALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNVRVECIGWSS
TSCHDGISRMSICMSGPNNNASAVVWYGGRPVTEIPSWAGNILRTQESEC
VCHKGICPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAVGVIKCVCRDNWKGANRPVITIDPEMMTHTSKYLCSKILTDTSRPND
PTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVP
NAETDTQSGPISHQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRG
RPKESSVLWTSNSIVALCGSKERLGSWSWHDGAEIIYFK
3D structure
PDB4qn6 Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle.
ChainB
Resolution1.945 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D72 E199 R214 R293 Y327
Catalytic site (residue number reindexed from 1) D70 E197 R212 R291 Y325
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D215 G219 D246 P269 D213 G217 D244 P267
BS02 LNV B R39 E40 D72 R73 W100 E149 A168 E198 R214 R293 Y327 R37 E38 D70 R71 W98 E147 A166 E196 R212 R291 Y325
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qn6, PDBe:4qn6, PDBj:4qn6
PDBsum4qn6
PubMed24899180
UniProtQ2FCL6

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