Structure of PDB 4qj5 Chain B

Receptor sequence
>4qj5B (length=747) Species: 9606 (Homo sapiens) [Search protein sequence]
QLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEV
DTLDISSIRDTRTGRYARLPKDPKIREVLGARLEEKLMTVVSGPDPVNTV
FLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQ
DGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERF
LNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPP
LRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLS
TDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVW
KGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHV
DSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVK
NKKREMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPM
EFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQ
LNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVIS
GQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFP
KVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLC
LPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIG
3D structure
PDB4qj5 Molecular mechanisms of phospholipase C beta 3 autoinhibition.
ChainB
Resolution3.41 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H332 N333 E362 D364 H379 E413
Catalytic site (residue number reindexed from 1) H316 N317 E346 D348 H363 E397
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B N333 E362 D364 E413 N317 E346 D348 E397
BS02 I3P B N333 E362 H379 E413 S619 Y648 N317 E346 H363 E397 S485 Y514
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qj5, PDBe:4qj5, PDBj:4qj5
PDBsum4qj5
PubMed25435326
UniProtQ01970|PLCB3_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (Gene Name=PLCB3)

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