Structure of PDB 4qj4 Chain B

Receptor sequence
>4qj4B (length=749) Species: 9606 (Homo sapiens) [Search protein sequence]
QLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEV
DTLDISSIRDTRTGRYARLPKDPKIREVLGDARLEEKLMTVVSGPDPVNT
VFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVN
QDGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFER
FLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYP
PLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDL
STDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDV
WKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENH
VDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILV
KNKKREMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSP
MEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAM
QLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI
SGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDF
PKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPL
CLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGE
3D structure
PDB4qj4 Molecular mechanisms of phospholipase C beta 3 autoinhibition.
ChainB
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H332 N333 E362 D364 H379 E413
Catalytic site (residue number reindexed from 1) H317 N318 E347 D349 H364 E398
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B N333 E362 D364 E413 N318 E347 D349 E398
BS02 I3P B H332 N333 E362 E413 S619 R646 Y648 H317 N318 E347 E398 S486 R513 Y515
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qj4, PDBe:4qj4, PDBj:4qj4
PDBsum4qj4
PubMed25435326
UniProtQ01970|PLCB3_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (Gene Name=PLCB3)

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