Structure of PDB 4qj1 Chain B

Receptor sequence
>4qj1B (length=345) Species: 5807 (Cryptosporidium parvum) [Search protein sequence]
AMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSA
MDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAI
GVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGN
VVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSV
ASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELI
GDTVYKYYRGMGSVGAMKSNKMVPEGIEGRVKYKGEMEGVVYQLVGGLRS
CMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYS
3D structure
PDB4qj1 Co-crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from Cryptosporidium parvum with inhibitor N109
ChainB
Resolution2.415 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP B S48 M50 G216 S217 I218 C219 D252 G275 S276 Y299 G301 M302 G303 E329 S49 M51 G175 S176 I177 C178 D211 G234 S235 Y258 G260 M261 G262 E275
BS02 N09 B A165 H166 M302 G303 E329 A124 H125 M261 G262 E275 BindingDB: IC50=20nM
BS03 N09 B S354 G357 Y358 S300 G303 Y304 BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qj1, PDBe:4qj1, PDBj:4qj1
PDBsum4qj1
PubMed
UniProtQ8T6T2|IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase (Gene Name=56k.02)

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