Structure of PDB 4qil Chain B

Receptor sequence
>4qilB (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
DTKHYEEAKKCVEELALYLKVLSRPMQRKLVTLVHCQLVEEEGRIRAMRA
ARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLV
LLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKV
TKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLL
YGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHL
ELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHS
3D structure
PDB4qil The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B W184 F194 R219 K220 S238 K239 T240 Q247 Y250 R251 S253 E262 D263 S264 W77 F87 R112 K113 S131 K132 T133 Q140 Y143 R144 S146 E155 D156 S157
External links
PDB RCSB:4qil, PDBe:4qil, PDBj:4qil
PDBsum4qil
PubMed25026078
UniProtQ5TC82|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)

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