Structure of PDB 4qik Chain B

Receptor sequence
>4qikB (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
SGVEDTKHYEEAKKCVEELALYLKPLVLSRPMQRKLVTLVHCQLVEEEGR
IRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQE
EALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYR
ASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPD
QWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLN
RLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNH
3D structure
PDB4qik The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R131 P132 R135 K136 R30 P31 R34 K35
BS02 rna B S315 Q318 S319 D322 S214 Q217 S218 D221
External links
PDB RCSB:4qik, PDBe:4qik, PDBj:4qik
PDBsum4qik
PubMed25026078
UniProtQ5TC82|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)

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