Structure of PDB 4qi9 Chain B

Receptor sequence
>4qi9B (length=159) Species: 214092 (Yersinia pestis CO92) [Search protein sequence]
MIISLIAALAADRVIHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGR
LNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRA
NRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILE
RRGENLYFQ
3D structure
PDB4qi9 Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate
ChainB
Resolution2.297 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I6 D28 L29 F32 L55 V92 T114
Catalytic site (residue number reindexed from 1) I6 D20 L21 F24 L47 V84 T106
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTX B I6 A7 D28 K33 R53 R58 M95 I6 A7 D20 K25 R45 R50 M87
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4qi9, PDBe:4qi9, PDBj:4qi9
PDBsum4qi9
PubMed
UniProtA0A3N4BLI0

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