Structure of PDB 4qi7 Chain B

Receptor sequence

>4qi7B (length=792) Species: 367110 (Neurospora crassa OR74A)

TAPKTFTHPDTGIVFNTWSASDSQTKGGFTVGMALPSNALTTDATEFIGY
LECSSAKNGANSGWCGVSLRGAMTNNLLITAWPSDGEVYTNLMFATGYAM
PKNYAGDAKITQIASSVNATHFTLVFRCQNCLSWDQDGVTGGISTSNKGA
QLGWVQAFPSPGNPTCPTQITLSQHDNGMGQWGAAFDSNIANPSYTAWAA
KATKIAATPVPTGVSFDYIVVGGGAGGIPVADKLSESGKSVLLIEKGFAS
TGEHGGTLKPEWLNNTSLTRFDVPGLCNQIWKDSDGIACSDTDQMAGCVL
GGGTAINAGLWYKPYTKDWDYLFPSGWKGSDIAGATSRALSRIPGTTTPS
QDGKRYLQQGFEVLANGLKASGWKEVDSLKDSEQKNRTFSHTSYMYINGE
RGGPLATYLVSAKKRSNFKLWLNTAVKRVIREGGHITGVEVEAFRNGGYS
GIIPVTNTTGRVVLSAGTFGSAKILLRSGIGPKDQLEVVKASADGPTMVS
NSSWIDLPVGHNLVDHTNTDTVIQHNNVTFYDFYKAWDNPNTTDMNLYLN
GRSGIFAQAAPNIGPLFWEEITGADGIVRQLHWTARVEGSFETPDGYAMT
MSQYLGRGATSRGRMTLSPTLNTVVSDLPYLKDPNDKAAVVQGIVNLQKA
LANVKGLTWAYPSANQTAADFVDKQPVTYQSRRSNHWMGTNKMGTDDGRS
GGTAVVDTNTRVYGTDNLYVVDASIFPGVPTTNPTAYIVVAAEHAAAKIL
AQPANEAVPKWGWCGGPTYTGSQTCQAPYKCEKQNDWYWQCV

3D structure

• PDB: 4qi7 Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation.
• Chain: B
• Resolution: 2.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T557 S616 Y618 S698 H700 T746 N747
• Catalytic site (residue number reindexed from 1): T543 S602 Y604 S684 H686 T732 N733

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	B	W65 G67 M74 L79 T81 Y99 M101 W155 V156 S174 Q175 H176 M180	W64 G66 M73 L78 T80 Y98 M100 W154 V155 S173 Q174 H175 M179
BS02	FAD	B	G236 G238 A239 E259 K260 W295 G316 G317 N321 A439 V440 A480 G481 N699 A737 N747 T749 I752	G222 G224 A225 E245 K246 W281 G302 G303 N307 A425 V426 A466 G467 N685 A723 N733 T735 I738
BS03	MAN	B	T222 G461	T208 G447

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0016787 hydrolase activity
• GO:0030248 cellulose binding
• GO:0046872 metal ion binding
• GO:0047735 cellobiose dehydrogenase (acceptor) activity
• GO:0050660 flavin adenine dinucleotide binding

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:4qi7, PDBe:4qi7, PDBj:4qi7
• PDBsum: 4qi7
• PubMed: 26151670
• UniProt: Q7RXM0