Structure of PDB 4qgg Chain B

Receptor sequence
>4qggB (length=195) Species: 282458 (Staphylococcus aureus subsp. aureus MRSA252) [Search protein sequence]
SAFITFEGPEGSGKTTVINEVYHRLVKDYDVIMTREPGGVPTGEEIRKIV
LEGNDMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQ
GYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERIIDQEDLKFH
EKVIEGYQEIIHNESQRFKSVNADQPLENVVEDTYQTIIKYLEKI
3D structure
PDB4qgg Antibacterial inhibitors of gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
ChainB
Resolution1.62 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 32C B E37 R48 F66 S69 R70 R92 S96 S97 Y100 Q101 E36 R47 F65 S68 R69 R91 S95 S96 Y99 Q100 MOAD: ic50=1nM
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4qgg, PDBe:4qgg, PDBj:4qgg
PDBsum4qgg
PubMed24828090
UniProtQ6GJI9|KTHY_STAAR Thymidylate kinase (Gene Name=tmk)

[Back to BioLiP]