Structure of PDB 4qg5 Chain B

Receptor sequence

>4qg5B (length=559) Species: 5664 (Leishmania major)

TANFVQSTFNALHRQGAVPDVLVVGGDGRYYTSEAVQVILKVSAANGVRC
VWVGQHGLLSTPAVSTMVRRRRDADGRKATGAFILTASHNPGGPDADFGI
KYNSENGGPAPEKLTSQIYEETVKITHIKMAPTLPEVDIHTLGTYTFDDY
NFQVEVVDSLADYAAYMQEVFDFEAIRALVQRLDFKVHVDSLHGVSGPYV
DRIFHEGLGVPKTSLFRTNVLPDFGGCHPDPNLTYAADLVHVMGLLPDGN
ANPAMKHISTVPSFGVAFDGDADRNMILGCRFFVNPSDSLAVLAANADCV
PFFTQSSSSGLKAVARSMPTSGAVDRVAAAHDFALFEVPTGWKFFGNLMD
SKDLYGGKDFNPLLCGEESFGTGSNHIREKDGIWASLFWLSVIAKRNAPG
TPLVGVQQIVEEHWATYGRNYYSRYDYEDVSAEAAKAVMDTVENTVVDDV
PNLNGVACKTIDNFSYTDPIDGSVSTKQGVRVLFEDGSRFVLRLSGTGSS
GATIRLYLEQYMDSATVKSHLAEKTLPTASTALKALIGVALQVSKMESLT
GRKTPTVIT

3D structure

• PDB: 4qg5 Crystal structure of phosphoglucomutase from Leishmania major at 3.5 angstrom resolution
• Chain: B
• Resolution: 3.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S118 H119 D299 D301 D303 R304 K410
• Catalytic site (residue number reindexed from 1): S88 H89 D269 D271 D273 R274 K380
• Enzyme Commision number: 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	S118 D299 D301 D303	S88 D269 D271 D273

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004614 phosphoglucomutase activity
• GO:0016853 isomerase activity
• GO:0016868 intramolecular phosphotransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4qg5, PDBe:4qg5, PDBj:4qg5
• PDBsum: 4qg5
• UniProt: Q4QCF1