Structure of PDB 4qfh Chain B

Receptor sequence

>4qfhB (length=611) Species: 5693 (Trypanosoma cruzi)

HHHHMKDQYLKDLTVHLNESNAAPANTSMAVASFNMPHEITRRMRPLGVD
ADTSLTSCPSWRRLQELYEIHGSESILKNFDECKDRFQRYSLEVDLRSSD
KNFVFLDYSKTHINDEIKDVLFKLVEERGIRAFMRALFAGEKVNTAENRS
VLHIALRNRSNRPIFVNGHDVMPLVNKVLEQMKKLSEKVRRGEWKGQSGK
PIRHVVNIGIGGSDLGPMMACEALRPFSDRRISMHFVSNIDGTHLSEVLN
LVDLESTLFIIASKTFTTQETITNALSARNEFLKFLSSRGISEAGAVAKH
FVALSTNAEKVKEFGIDEENMFQFWDWVGGRYSLWSAIGLSVMISIGYDN
FVELLTGAHIMDEHFINAPTENNLPIILALVGIWYNNFFGSETQAILPYD
QYLWRLPAYLQQLDMESNGKGATKNGRMVSTHTGPIIFGEAGTNGQHAFY
QLIHQGTKLIPCDFIGAIQTQNYIGEHHRILMSNFFAQTEALMIGKTPEE
VKRELESAGGKSEDEIQLLIPQKTFTGGRPSNSLLVKALTPRALGAIIAM
YEHKVLVQGAIWGINSYDQWGVELGKLLAKSILLQLQPGQKVTNHDSSTN
GLIELFNERSH

3D structure

• PDB: 4qfh Structure of a glucose-6-phosphate isomerase from Trypanosoma cruzi
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K260 E266 G326 R327 E412 H443 K572
• Catalytic site (residue number reindexed from 1): K264 E270 G330 R331 E416 H447 K576
• Enzyme Commision number: 5.3.1.9: glucose-6-phosphate isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	G6P	B	I206 G208 S259 K260 T261 T264 E412 K572	I210 G212 S263 K264 T265 T268 E416 K576

Gene Ontology

Molecular Function

• GO:0004347 glucose-6-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0048029 monosaccharide binding
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0051156 glucose 6-phosphate metabolic process
• GO:1901135 carbohydrate derivative metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4qfh, PDBe:4qfh, PDBj:4qfh
• PDBsum: 4qfh
• UniProt: Q4E5N1