Structure of PDB 4qc6 Chain B

Receptor sequence
>4qc6B (length=179) Species: 1292 (Staphylococcus warneri) [Search protein sequence]
MNIVENEICIRTLIDDDFPLMLKWLTDERVLEFYGGRDKKYTLESLKKHY
TEPWEDEVFRVIIEYNNVPIGYGQIYKMYDELYTDYHYPKTDEIVYGMDQ
FIGEPNYWSKGIGTRYIKLIFEFLKKERNANAVILDPHKNNPRAIRAYQK
SGFRIIEDLPEHELHEGKKEDCYLMEYRY
3D structure
PDB4qc6 Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.
ChainB
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAN B Y34 G35 H49 Y50 E52 W54 R60 Q74 H138 E163 Y34 G35 H49 Y50 E52 W54 R60 Q74 H138 E163
BS02 30N B F33 Q100 F101 I102 W108 S109 G111 G113 T114 P137 N141 R143 A144 R146 A147 Y148 K150 F33 Q100 F101 I102 W108 S109 G111 G113 T114 P137 N141 R143 A144 R146 A147 Y148 K150
Gene Ontology
Molecular Function
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:4qc6, PDBe:4qc6, PDBj:4qc6
PDBsum4qc6
PubMed25286858
UniProtQ7ATH7|AACA_STAWA Bifunctional AAC/APH (Gene Name=aacA-aphD)

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