Structure of PDB 4qae Chain B

Receptor sequence
>4qaeB (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
TSDLIPAPPLSKVPLQQNFQDNQFHGKWYVVGLAGNEVLREDKDPMKMWA
TIYELEEDKSYNVTIVMPLAEKCEYLFQTFVPGSQPGEFTLGGIKSGPGR
TSGLVRVVSTNYNQHAMVFFKVVWQNREVFWVTLYGRTKELTSELKENFI
RFSKSLGLPENHIVFPVPIDQCIDG
3D structure
PDB4qae Structure of a hepcidin-binding anticalin in complex with its peptide ligand
ChainB
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I55 E57 E59 N65 C76 Y78 F80 Q174 C175 I52 E54 E56 N62 C73 Y75 F77 Q171 C172
BS02 peptide B E40 L42 E44 W52 I68 M70 L79 Q81 V125 W127 V132 W134 E37 L39 E41 W49 I65 M67 L76 Q78 V122 W124 V129 W131
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0036094 small molecule binding
GO:0042802 identical protein binding
GO:0140315 iron ion sequestering activity
GO:1903981 enterobactin binding
Biological Process
GO:0006826 iron ion transport
GO:0006915 apoptotic process
GO:0015891 siderophore transport
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031410 cytoplasmic vesicle
GO:0035580 specific granule lumen
GO:0060205 cytoplasmic vesicle lumen
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4qae, PDBe:4qae, PDBj:4qae
PDBsum4qae
PubMed
UniProtP80188|NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (Gene Name=LCN2)

[Back to BioLiP]