Structure of PDB 4q40 Chain B

Receptor sequence
>4q40B (length=335) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCG
DIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVI
VGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLS
FLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIA
YFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGT
AVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAV
HILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
3D structure
PDB4q40 Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
ChainB
Resolution1.831 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H131 D154 H156 D158 H171 D262 D264 E307
Catalytic site (residue number reindexed from 1) H105 D128 H130 D132 H145 D236 D238 E281
Enzyme Commision number 3.5.3.1: arginase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H131 D154 D158 D262 H105 D128 D132 D236
BS02 MN B D154 H156 D262 D264 D128 H130 D236 D238
BS03 VAL B S167 G172 D213 S141 G146 D187
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0006525 arginine metabolic process
GO:0019547 arginine catabolic process to ornithine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4q40, PDBe:4q40, PDBj:4q40
PDBsum4q40
PubMed25007099
UniProtQ6WVP6

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