Structure of PDB 4q3r Chain B

Receptor sequence
>4q3rB (length=333) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCG
DIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSKSTPLVIV
GGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSF
LVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAY
FTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTA
VPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVH
ILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHM
3D structure
PDB4q3r Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
ChainB
Resolution2.169 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H131 D154 H156 D158 H171 D262 D264 E307
Catalytic site (residue number reindexed from 1) H104 D127 H129 D131 H144 D235 D237 E280
Enzyme Commision number 3.5.3.1: arginase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H131 D154 D158 D262 H104 D127 D131 D235
BS02 MN B D154 H156 D262 D264 D127 H129 D235 D237
BS03 XA2 B D154 H156 D158 N160 S167 H171 D213 D262 E307 D127 H129 D131 N133 S140 H144 D186 D235 E280 MOAD: Kd=0.54uM
PDBbind-CN: -logKd/Ki=6.27,Kd=0.54uM
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0006525 arginine metabolic process
GO:0019547 arginine catabolic process to ornithine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4q3r, PDBe:4q3r, PDBj:4q3r
PDBsum4q3r
PubMed25007099
UniProtQ6WVP6

[Back to BioLiP]