Structure of PDB 4q15 Chain B

Receptor sequence
>4q15B (length=458) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQAFF
NKEIKKLNVENSYFPLFVTKNKLEGFSPEVAWVTKYGDSNLPEEIAIRPT
SETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPFIRTREFLWQE
GHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKFGGANF
TSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQYVHQTSW
GCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFYKTTDENAIHSYC
KDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPKDLQNN
SCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLDDSIVQV
TSFSEVMNALNKKKMVLAPWCAMKPLCIPLDQPPMPPNMKCFWSGKPAKR
WCLFGRSY
3D structure
PDB4q15 Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B R390 E392 R401 T402 F405 Q475 A476 A477 T478 T512 R514 R131 E133 R142 T143 F146 Q216 A217 A218 T219 T253 R255
BS02 HFG B F335 E338 P358 T359 E361 R390 F454 T478 H480 W509 G510 F76 E79 P99 T100 E102 R131 F195 T219 H221 W250 G251 MOAD: ic50=275nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4q15, PDBe:4q15, PDBj:4q15
PDBsum4q15
PubMed27798837
UniProtQ8I5R7|SYP_PLAF7 Proline--tRNA ligase (Gene Name=proRS)

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