Structure of PDB 4pz6 Chain B

Receptor sequence
>4pz6B (length=372) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
SMAPSEKDIEEVSVPGVLAPRDDVRVLKTRIAKLLGTSPDTFPGSQPVSF
SKKHLQALKEKNYFVCEKSDGIRCLLYMTEHPRYENRPSVYLFDRKMNFY
HVEKIFYPVENDKSGKKYHVDTLLDGELVLDIYPGGKKQLRYLVFDCLAC
DGIVYMSRLLDKRLGIFAKSIQKPLDEYTKTHMRETAIFPFLTSLKKMEL
GHGILKLFNEVIPRLRHGNDGLIFTCTETPYVSGTDQSLLKWKPKEMNTI
DFMLKLEFAQPEEGDIDYSAMPEFQLGVWEGRNMYSFFAFMYVDEKEWEK
LKSFNVPLSERIVECYLDDENRWRFLRFRDDKRDANHISTVKSVLQSIED
GVSKEDLLKEMPIIREAYYNRK
3D structure
PDB4pz6 How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes.
ChainB
Resolution2.406 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F63 R157 D160 K161 G164 L194 M197 L199 R364 Y368 F64 R158 D161 K162 G165 L195 M198 L200 R365 Y369
BS02 GMP B R72 E126 F144 K195 R73 E127 F145 K196
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004484 mRNA guanylyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
GO:0099122 RNA polymerase II C-terminal domain binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0005634 nucleus
GO:0031533 mRNA capping enzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pz6, PDBe:4pz6, PDBj:4pz6
PDBsum4pz6
PubMed24939935
UniProtP40997|MCE1_SCHPO mRNA-capping enzyme subunit alpha (Gene Name=ceg1)

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