Structure of PDB 4pw5 Chain B

Receptor sequence
>4pw5B (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
IVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLV
LAGGFADEVDRGDEFTYTGSGSADQTLTNMNRALALNCDAPLDDKIGAES
RNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGF
LVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGY
3D structure
PDB4pw5 Structural Basis for Hydroxymethylcytosine Recognition by the SRA Domain of UHRF2.
ChainB
Resolution2.204 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B F461 R462 V475 G477 A492 G494 Y507 T508 K569 F21 R22 V35 G37 A52 G54 Y67 T68 K116
External links
PDB RCSB:4pw5, PDBe:4pw5, PDBj:4pw5
PDBsum4pw5
PubMed24813944
UniProtQ96PU4|UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2 (Gene Name=UHRF2)

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