Structure of PDB 4pvz Chain B

Receptor sequence

>4pvzB (length=422) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

ELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVE
FMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSV
EVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATW
TLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDG
PQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVV
INAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPP
LVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLL
EIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIF
NCQQNENDKIYEKAYKIIETYF

3D structure

PDB

4pvz Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Q113 L115 S116 R117 E118 P121 W153 N157 A159 S160 G161 T162 Q192 W195 N199 G202 D203 W237 R244 K246 D286 G287 R321 N325 V327 T328 G329 E360 W363 N367 A370 E402 W405 N409	Q26 L28 S29 R30 E31 P34 W66 N70 A72 S73 G74 T75 Q105 W108 N112 G115 D116 W150 R157 K159 D199 G200 R234 N238 V240 T241 G242 E273 W276 N280 A283 E315 W318 N322

External links

PDB	RCSB:4pvz, PDBe:4pvz, PDBj:4pvz
PDBsum	4pvz
PubMed	26051712
UniProt	Q02821\|IMA1_YEAST Importin subunit alpha (Gene Name=SRP1)

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