Structure of PDB 4prq Chain B

Receptor sequence

>4prqB (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

3D structure

• PDB: 4prq Protein assembly mediated by sulfonatocalix[4]arene.
• Chain: B
• Resolution: 1.72 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	T3Y	B	C6 G126 C127 R128	C6 G126 C127 R128
BS02	T3Y	B	K1 F3 R14 H15 S86 D87 I88	K1 F3 R14 H15 S86 D87 I88
BS03	T3Y	B	R61 W62 G102 N103 N106	R61 W62 G102 N103 N106

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:4prq, PDBe:4prq, PDBj:4prq
• PDBsum: 4prq
• PubMed: 25068633
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)