Structure of PDB 4pp6 Chain B

Receptor sequence
>4pp6B (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4pp6 Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.
ChainB
Resolution2.201 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 E380 D538 L539 E542 I50 K54 E72 D220 L221 E224
BS02 STL B M343 L349 E353 L387 M388 L391 H524 L525 M35 L41 E45 L79 M80 L83 H206 L207 BindingDB: Ki=785nM
External links
PDB RCSB:4pp6, PDBe:4pp6, PDBj:4pp6
PDBsum4pp6
PubMed24771768
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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