Structure of PDB 4pip Chain B

Receptor sequence
>4pipB (length=309) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
SAAEALRRDVRAGLTATQKSLPPKWFYDAVGSDLFDQITRLPEYYPTRTE
AQILRTRSAEIISAAGADTLVELGSGTSEKTRMLLDAMRDAELLRRFIPF
DVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPHVGRRLVVFLGS
TIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGRLVRAYDDAAGV
TAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIEVWLRARTAQHV
RVAALDLEVDFAAGEEMLTAVSCKFRPENVVAELAEAGLRQTHWWTDPAG
DFGLSLAVR
3D structure
PDB4pip Ergothioneine Biosynthetic Methyltransferase EgtD Reveals the Structural Basis of Aromatic Amino Acid Betaine Biosynthesis.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.44: L-histidine N(alpha)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TRP B F47 Y56 N166 Y206 F216 S284 F35 Y44 N154 Y194 F204 S272
BS02 SAH B K36 Y39 F47 G86 K92 D113 V114 D141 F142 K24 Y27 F35 G74 K80 D101 V102 D129 F130
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0052706 L-histidine N(alpha)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:4pip, PDBe:4pip, PDBj:4pip
PDBsum4pip
PubMed25404173
UniProtA0R5M8|EGTD_MYCS2 Histidine N-alpha-methyltransferase (Gene Name=egtD)

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