Structure of PDB 4ph4 Chain B

Receptor sequence
>4ph4B (length=529) Species: 9606 (Homo sapiens) [Search protein sequence]
SGIRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNW
DLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADD
EDLLMYLLQLVQALKYENFDDIKNGLEPLEQDLCTFLISRACKNSTLANY
LYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLL
AAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIP
LPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLR
QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAE
VLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVG
DRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQS
EQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKV
QDKFRLDLSDEEAVHYMQSLIDESVHALF
3D structure
PDB4ph4 Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2UG B F612 I634 K636 Y670 M682 F684 I685 S687 L750 I760 F270 I292 K294 Y328 M340 F342 I343 S345 L408 I418 PDBbind-CN: -logKd/Ki=7.74,IC50=18nM
BindingDB: IC50=18nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ph4, PDBe:4ph4, PDBj:4ph4
PDBsum4ph4
PubMed25327288
UniProtQ8NEB9|PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (Gene Name=PIK3C3)

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