Structure of PDB 4pfy Chain B

Receptor sequence

>4pfyB (length=537) Species: 243274 (Thermotoga maritima MSB8)

FERNKTLYWGGALWSPPSNWNPFTPWNAVAGTIGLVYEPLFLYDPLNDKF
EPWLAEKGEWVSNNEYVLTLRKGLRWQDGVPLTADDVVFTFEIAKKYTGI
SYSPVWNWLGRIERVDERTLKFVFSDPRYQEWKQMLINTPIVPKHIWENK
TEEEVLQAANENPVGSGPYYVESWADDRCVFKKNGNWWGIRELGYDPKPE
RIVELRVLSNNVAVGMLMKGELDWSNFFLPGVPVLKKAYGIVTWYENAPY
MLPANTAGIYINVNKYPLSIPEFRRAMAYAINPEKIVTRAYENMVTAANP
AGILPLPGYMKYYPKEVVDKYGFKYDPEMAKKILDELGFKDVNKDGFRED
PNGKPFKLTIECPYGWTDWMVSIQSIAEDLVKVGINVEPKYPDYSKYADD
LYGGKFDLILNNFTTGVSATIWSYFNGVFYPDAVESEYSYSGNFGKYANP
EVETLLDELNRSNDDAKIKEVVAKLSEILLKDLPFIPLWYNGAWFQASEA
VWTNWPTEKNPYAVPIGWNGWWQLTGIKTLFGIEAKH

3D structure

• PDB: 4pfy Duplication of Genes in an ATP-binding Cassette Transport System Increases Dynamic Range While Maintaining Ligand Specificity.
• Chain: B
• Resolution: 1.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	B	S122 E152 Y451 S462	S101 E131 Y430 S441
BS02	BMA	B	N159 S462	N138 S441
BS03	BMA	B	Y461 N540	Y440 N519
BS04	BMA	B	F434 N540	F413 N519
BS05	BMA	B	A33 N433 F434 W539	A12 N412 F413 W518
BS06	BMA	B	N231 N247 F248 F249 W387 D389 W390 W515	N210 N226 F227 F228 W366 D368 W369 W494
BS07	MG	B	D362 N364 D366 F368 E370	D341 N343 D345 F347 E349

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding
• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:4pfy, PDBe:4pfy, PDBj:4pfy
• PDBsum: 4pfy
• PubMed: 25210043
• UniProt: Q9X0V0