Structure of PDB 4pfm Chain B

Receptor sequence
>4pfmB (length=295) Species: 314608 (Shewanella benthica KT99) [Search protein sequence]
HMINGSIVALITPLNSDGTVDYTSLEKLVEYHITEGTDAIVAVGTTGESA
TLPISEHIAVVGQTVKFASGRIPVIGGNGANATAEAIELTKAQNKLGVAA
MLGVTPYYNKPSPKGLIAHYTAVAASTDIPQILYNVPGRTAVDMLPETIA
QLVEVPNIIGVKDATGDVARVKQLRDLCGNDFLLYSGDDATAREFLTLGG
DGVISVANNIVPKLFKLMCDAALAGDTQAAMAAEDQIKGLFSALFCEANP
IPVKWAAHKMGLISQGDIRLPLTELSTEFHGLLLDAMKNARIEVK
3D structure
PDB4pfm Defining a Molecular Determinant of Lysine-Mediated Allosteric Inhibition of DHDPS.
ChainB
Resolution2.327 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T44 Y107 Y133 R138 K161 I203
Catalytic site (residue number reindexed from 1) T45 Y108 Y134 R139 K162 I204
Enzyme Commision number 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYS B N80 E84 N81 E85
BS02 LYS B L51 H56 Y106 L52 H57 Y107
BS03 LYS B A83 E84 E87 A84 E85 E88
Gene Ontology
Molecular Function
GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0019877 diaminopimelate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pfm, PDBe:4pfm, PDBj:4pfm
PDBsum4pfm
PubMed
UniProtA9DKW4

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