Structure of PDB 4pa0 Chain B

Receptor sequence
>4pa0B (length=920) Species: 6100,9606 [Search protein sequence]
GDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKI
VSREGGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAV
LYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAP
PHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAI
GDRSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATG
KLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNN
PYDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAI
MHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVTK
GQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIA
GFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDF
GMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANF
QKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSS
LKLLSTLFANYFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPG
VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAASRK
GAEKLLSSNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRTPILVELD
GDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTFVQCFS
RYPDHMKRHDFFKSAMPEGYVQERTIFFGNYKTRAEVKTLVNRIELKEYN
YNSHNVYIMADKQKNGIKANFKTRHNIELADHYQQNTPILLPDNHYLSTQ
SALSKRDHMVLLEFVTAAGI
3D structure
PDB4pa0 Structural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity.
ChainB
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 G181 T185 N238 S241 S242 G464 E466
Catalytic site (residue number reindexed from 1) S179 G180 T184 N232 S235 S236 G451 E453
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2OW B A91 M92 S118 F121 V698 G701 I702 C705 P710 N711 R712 A90 M91 S117 F120 V666 G669 I670 C673 P678 N679 R680 MOAD: Ki=100nM
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0008218 bioluminescence
Cellular Component
GO:0005575 cellular_component
GO:0016459 myosin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pa0, PDBe:4pa0, PDBj:4pa0
PDBsum4pa0
PubMed26246073
UniProtP12883|MYH7_HUMAN Myosin-7 (Gene Name=MYH7);
P42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP)

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